Overal Seven years of experience in Drug discovery on anticancer drugs on FGFR1, CK2 and Pim kinase as a Junior scientist ,Process research and development . In addition to my experience in my functional area i.e. designing of small molecules for target of drug discovery,new patent analyzing,patent file,I have a wide range of experience in synthetic routs scouting, costing, pricing and Quality drug management system for the commercial Drug Discovery.Professional strength:
** Synthesis of verities of NCE and Drug intermediates on the basis of invitro,invivo and preclinical
** Synthesis, Reactions using Parallel Synthesizers
** Patent search for updating the project status.
** Chemical search from different vendors.
** Literature collection (Beilstein, Crossfire, Scifinder, Reaxys)
** Quotation for project from small molecules to final molecules
** Coordinating with all departmentsExperience :
** Presently working with Aurigene Discovery Technologies Ltd, as a junior scientist, Electronic city, Bangalore since 2009 to still.
** Previously two years worked with Chembiotek Research International Pvt Ltd (A TCG Life Sciences Ltd), As Research chemist, CRO. Saltlake ,Kolkata
** Previously worked with Dr ReddysLabs Ltd as a Process Rresearch Chemist, Jedimetla,Hyderabad
** Previously worked with Surya Pharmaceuticals Ltd as trainee Research chemist ,Panchakulla,Chandigarh,HaryanaEducational qualification:
** M.Sc. Sponsored links :
(Organic Chemistry) from GITAM College Visakhapatnam, Andhra University.
** B.Sc. (Maths,Physics,Chemistry) from Govt. Degree College, Mandapet, Andhra University, in 2003.
Experience on synthetic organic chemistry
** Handling the air sensitive Reactions and sealed tube reactions.
** Reactions conducted from 5mg to 100gms and plant scale
** Monitoring reaction through TLC analysis (Iodine, KMnO4, Ninhydrine, UV Chamber)
** Enough experience on Multi steps organic synthesis
** Separation of a mixture of compound through column chromatography, combiflash chromatography, biotage and SCX Column chromatography
Characterization of NCE by Spectral data Proton NMR, C13 NMR Spectroscopy, UV, IR, LCMS and HPLC
Handled reactions and reagents
** Hydrogenation, Friedalcraft reaction, Suzuki coupling, negishcoupling
** Vilsmeier , DarzenReaction, ClemensonReduction,
** Amide couplings,Urea formation, Grignard reagent & reactions, witting reaction ,
** Heck reaction , swarm oxidation
** LiAlH4 ,NaBH4, AlCl3,NaIO4,KMno4,NaOMe,NaCNBH3
** LDA, n-Butyl lithium, t-Butyl lithium, NaH, Raney Nickel, Pd/c, etc
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