OBJECTIVE :
To work with an organization of distinction in Pharmacy sector which recognizes my true potential and provides me sufficient avenues for professional growth through nurturing my skills and competencies
PROFILE & STRENGTHS :
A young and dynamic individual with a strong academic background completed M. Pharm from AISSMS College of Pharmacy, Pune.
Recently published research articles in well know international journals; “European Journal of Medical Chemistry” and “Journal of Enzyme Inhibition and Medicinal Chemistry”
Successfully qualified GATE 2007 conducted by Indian Institute of Technology (IIT), Kanpur with 94.08 Percentile (AIR 1079, GATE Score 413).
Received Junior Research Fellowship (20072009) by Govt. of India, Ministry of Human Resource development (MHRD) GATEScholarship for two years from 20072009.
Multilingual with proficiency in English, Hindi and Marathi.
Areas of Interest :
Research and Development ComputerAided Drug Design Quality Assurance Intellectual Property Rights & Drug Regulatory Affairs Development of Selective Therapeutic Agents
ACADEMIC CREDENTIALS :
M.Pharm (Pharmaceutical Chemistry) (2009)
AISSMS College of Pharmacy, Pune
B.Pharm (2007) :
Sudhakarrao Naik Institute of Pharmacy, Pusad
D.Pharm (2004) :
Geetadevi Khandelwal Institute of Pharmacy, Akola
HSC (2002) :
Akola Arts, Commerce and Science Jr. College, Akola
SSC (2000) :
Guru Nanak Vidyalaya, Akola
PROJETCS UNDERTAKEN :
DISSERTATION PROJECT
Title : Development of selective Antineoplastic agents using Molecular modeling Studies
Abstract : 2D and 3D Quantitative Structure–Activity Relationship (QSAR) studies were carried out for establishing a correlation between the structural properties of Benzyl Urea derivatives and their antitumor activities. From this correlation, the New Chemical Entities (NCEs) were designed and the binding affinity of designed compounds was studied on Epidermal Growth Factor Receptor (EGFR) using docking studies and also their ADMET properties were predicted. Finally the most promising compounds from these screening were synthesized and biologically evaluated for their anticancer properties. Compound 1(2, 4dimethylphenyl)3, 3dimethyl1(2nitrobenzyl) urea (DL4) showed significant antiproliferative activity ( at 100 ug/ml ) in human cancer cell linesTcell leukemia (Jurkat J6), Myelogenous leukemia (K562) and Breast cancer (MCF7) compared to reference standard 5Flurouracil.
PUBLICATION AND PRESENTATIONS :
Presented a poster entitled “Pharmacophore Optimization of selective protein kinase inhibitors using Molecular modeling studies” at 60th Indian Pharmaceutical Congress 2008, Delhi.
Coauthor in Poster presentation entitled “Design and synthesis of novel anticancer agent using molecular modeling techniques” in Innovation 2008, at S.G.R.S.
College of Pharmacy, Saswad Pune.
Research article published in European journal of Medicinal Chemistry entitled “Design, Synthesis and Pharmacological Screening of Novel Nitric Oxide Donors Containing1, 5Diaryl Pyrazolin3One as Non Toxic NSAIDs” Vol. 44, No. 11, (Nov 2009) 4622–4636. http ://dx.doi.org/10.1016/j.ejmech.2009.06.035
Research article accepted in Journal of Enzyme Inhibition and Medicinal Chemistry entitled “Design, Synthesis and Evaluation of Antiinflammatory, Analgesic, Ulcerogenicity and Nitric oxide releasing studies of Novel Indomethacin analogs as Nonulcerogenic Derivatives”.
Research article accepted in Internet Electronic Journal of Molecular Design entitled “Design of New Chemicals Entities as Selective COX–2 inhibitors using Structure Optimization by Molecular modeling Studies”.
RESEARCH ARTICLES COMMUNICATED :
Prepared a research article communicated to European journal of Medicinal Chemistry entitled “Use of Quantitative Structure Activity Relationship (QSAR), Docking and ADMET Prediction Studies as Screening Methods for design of Benzyl Urea Derivatives for Anticancer Activity”.
Prepared a research article communicated to Medicinal Chemistry Research entitled “Design, Docking Study and ADME prediction of Isatin Derivatives as AntiHIV Agents”.
TECHNICAL/COMPUTER PROFICIENCIES :
Drug Design Software :
Well Conversant with handling of QSAR and Molecular Modeling Softwares like
Glide 5.0, Qikprop 3.1, Strike 1.7, Sitemap 2.2 by Schrodinger Inc. USA
Discovery Studio 2.1 by Accelrys, USA
Molecular Design Suite 3.5 by Vlife Sciences, Pune, India
Molegro Vertual Docker 2008, Denmark
qTox, q ADME, qhERG, qAlbumin by Quantum Lead, Russia
TSAR 3.3 by Oxford Molecular Ltd, Accelrys, USA
Chemoffice 2004 and 2008, CambridgeSoft
Familiar with Drug Design softwares like
Autodock 3.0.5, USA
FlexX 3.1, Germany
LigandScout 2.0, Austria/Europe
Analytical instrument, Handling Experience
UVVisible Spectrophotometer JASCO V530, Japan
FTIR InstrumentJASCO 460 Plus, Japan
Microwave Synthesis Station Catalyst, Pune, India
ADDITIONAL INFORMATION :
Date of Birth : December 31, 1984
Languages : Hindi, English, Marathi
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